By Levels, Committee On Acute Exposure Guideline
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Extra info for Acute exposure guideline levels for selected airborne chemicals : volume 14.
Exposure route/Concentrations/Durations: Aerosol inhalation; LCt50 of 37,000 mg-min/m3 based on exposure durations of 6-25 min. Effects: LCt50 of 37,000 mg-min/m3 based on exposure durations of 6-25 min. End point/Concentration/Rationale: Lethality threshold estimated as one-tenth of LCt50; definitive information regarding the concentration-response relationship for BZ is lacking. Uncertainty factors/Rationale: Total uncertainty factor: 100 Interspecies: 10, no lethality data are available for humans and LCt50 values for five animal species varied 10-fold.
10(6):861-867. 34 Acute Exposure Guideline Levels APPENDIX A DERIVATION OF AEGL VALUES FOR AGENT BZ Derivation of AEGL-1 Values Although exposures to BZ resulting in no apparent effects in animals were available, the experiments could not assess possible cognitive and behavioral effects characteristic of BZ that are relevant to humans. Human data on BZ that define no-effect levels or that are consistent with the AEGL-1 definition were not available. Thus, AEGL-1 values for BZ are not recommended.
R. Franz, eds. Office of the Surgeon General at TMM Publications, Borden Institute, Walter Reed Army Medical Center, Washington, DC. R. B. L. E. Vancil. 1967. The Human Assessment of BZ Disseminated Under Field Conditions. Edgewood Arsenal Technical Report EATR 4140. Medical Research Laboratory, Edgewood Arsenal, MD. , W. A. DeYoung. 2001. Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene. Pharm. Sci. 3(4):57-61. P. 1963. Toxicological Studies of Effects of BZ on Animals.
Acute exposure guideline levels for selected airborne chemicals : volume 14. by Levels, Committee On Acute Exposure Guideline