By Michael Williams (auth.), Michael Williams (eds.)
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Extra resources for Adenosine and Adenosine Receptors
Henn, F. , and Cancilla, P. A. (1984) Demonstration of adenosine receptors on mouse cerebral smooth muscle membmnes. Stroke 15,725-727. 46 Williams and Jacobson Braa8, K. , Zarbin, M. , and Snyder, S. H. (1987) Endogenous adenosine and adenosine receptors localized to ganglion cells of the retina. Proc. Natl. Acad. Sci. USA 84, 3906-3920. Bridges, A. 1, Bruns,R. , Ortwine, D. , Szotek,D. L. and Trivedi, B. K. (1988) ~-[2(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl] adenosine and its uronamide derivatives.
1989). , 1989a) and an apparent Bmax of 375 fmoVmg protein. CPA had no effect on the binding of rH]CGS 21680. 98 was obtained when the activity of a series of A2-selective agonists and antagonists in the PH]CGS 21680 assay was compared to data obtained using [3Ii]NECA in the presence of CPA. CGS 21680 is thus the first selective adenosine Az receptor ligand that can be used without the need to chemically or pharmacologically block Al receptor binding. 3. PAPA-APEC 1251-2-[ 4-[2-[2-[( 4-aminophenyl)methylcarbonylamino]ethylaminocarbonyl]ethyl]phenyl]ethylamino ethylamino-51-N-ethylcarboxamidoadenosine (Fig.
2 nMin rat brain and labeled approximately half as many sites as DPX, a more accurate reflection of At receptor labeling. , 1983b). The pharmacology of binding was similar to that seen with CHA. , 1986) with a Kd of 12 nM. XCC (Xanthine carboxylic acid congener or 1,3dipropyl-8-(4-carboxymethyloxy)phenylxanthine; Fig. 2) has also been radiolabeled and appears to be an At-selective ligand. , 1987). 4. PD 116,948 (CPX) PD 116, 948 or 1,3-dipropyl-8-cyclopentylxanthine (CPX or DPCPX; Fig. , 1987a).
Adenosine and Adenosine Receptors by Michael Williams (auth.), Michael Williams (eds.)