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Download e-book for kindle: Advanced Mechanical Models of DNA Elasticity by Yakov M Tseytlin

By Yakov M Tseytlin

ISBN-10: 0128019999

ISBN-13: 9780128019993

ISBN-10: 0128020369

ISBN-13: 9780128020364

Advanced Mechanical types of DNA Elasticity comprises assurance on 17 various DNA versions and the function of elasticity in organic capabilities with vast references. the radical complex helicoidal version defined displays the direct connection among the molecule helix constitution and its particular homes, together with nonlinear good points and transitions. It offers an advent to the nation of the sector of DNA mechanics, identified and familiar types with their brief research, in addition to insurance on experimental tools and knowledge, the impression of electric, magnetic, ionic stipulations at the patience size, and dynamics with viscosity impact. It then addresses the necessity to comprehend the character of the non-linear overstretching transition of DNA below strength and why DNA has a unfavourable twist-stretch coupling.

  • Includes insurance of 17 modern types of DNA mechanics with analysis
  • Provides comparability of DNA and RNA mechanical features
  • Covers advances in experimental ideas together with AFM, X-ray, and optical tweezers
  • Contains broad references for extra reading

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Additional info for Advanced Mechanical Models of DNA Elasticity

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1964. Fundamental equations of the theory of asymmetric elasticity. PMM 28 (3), 401, (in Russian). , 2008. Modeling DNA at the mesoscale: challenge for nonlinear science? Nonlinearity 21, T91–T100. , 2005. Genetics: A Conceptual Approach, second ed. H. Freeman, New York, NY. , 2011. /physics-of-DNA. , 2008. Discovery of DNA structure and function: Watson and Crick. Nat. Edu. , 1999. Sequence-dependent mechanics of single DNA molecules. Nature Struct. Biol. 6 (4), 346–349. , 1998. Diversity of prokaryotic chromosomal proteins and the origin of the nucleosome.

Ising model for B-Z transition in supercoiled DNA. Bul. Math. Biol. 54 (5), 727–732. , 2006. DNA overwinds when stretched. Nature 442, 836. , 1994. HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet. 10 (3), 94–100. , 2006. Investigation of the ssDNA backbone molecule mechanical behavior using atomistic-continuum mechanics method. In: Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, vol. 2. pp. 321–324. NSTI-Nanotech (Chapter 4).

The bead positioning software determines the DNA extension ∆LDNA and the particle transverse fluctuations dx. , 2010) through the formula Fmag = kBT ∆LDNA /<δ x 2 >. , 2013) have the ability to resolve particle position to within 1 Å at 100 Hz, and to measure the extension of 1566 bp DNA with 1 nm precision at 100 Hz, in the presence of thermal noise. The requirement for sufficient light at high frames rates is fulfilled with Force Application, Measurement, and Manipulation Accessories Chapter | 2 45 a super luminescent diode (SLD), and replacing the conventional 60 Hz CCD with a high-speed CMOS camera.

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Advanced Mechanical Models of DNA Elasticity by Yakov M Tseytlin

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