By M. M. Avram, D. Burrell, P. A. Slater, P. A. Fein, A. Antignani, N. Mittman, D. Tan (auth.), Morrell M. Avram M.D., F.A.C.P., Carmelo Giordano M.D., Natale G. DeSanto M.D., Neal Mittman M.D., Giorgio Bazzato, Paul A. Fein M.D., Amado Gan M.D., Philip Gold
The Fourth foreign Congress of Peritoneal Dialysis used to be held in Venice, Italy, June 29 to July 2, 1987. by way of this time peritoneal dialysis had emerged as a remedy for a considerable fraction of sufferers with end-stage renal disorder and 1000's of sufferers with acute renal failure. This remedy is now practiced all over the world and is the life-sustaining therapy for approximately 40,000 sufferers with power renal failure, representing 15 to twenty% of dialysis remedy in approximately one thousand facilities. it isn't extraordinary, for this reason, that the variety of overall healthiness pros engaged within the research and the appliance of the remedy has additionally grown exponen tially. the 1st foreign Symposium on Peritoneal Dialysis, geared up through Dr. A. Treviiio-Be cerra in Chapala, Mexico, in 1978, introduced jointly a gaggle of pioneers while non-stop ambulatory peritoneal dialysis used to be in its infancy. In 1981, Dr. G. M. Gahl chaired the second one Symposium, in West Berlin, whilst the approach curiosity have been starting to be con siderably. via 1984, whilst Dr. 1. F. Winchester and that i geared up the 3rd Symposium, the pre sented papers surpassed a hundred and there have been approximately one thousand attendees. at the moment, it was once deemed applicable to shape a extra prepared crew and the foreign Society for Peritoneal Dialy sis used to be based. one of many first activities of the Society was once to select from between numerous candidates Dr.
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RESULTS When dialysate volume at 1 h of rabbits undergoing hypertonic dialysis was calculated by dilution of the isotope indwelling for 60 min, the value was slightly but not significantly higher than that estimated by dilution of the marker instilled at 60 min (Fig. 1). The difference in the two values is attributed to absorption of the isotope. Figure 2 plots the UF rate as a function of dialysate dextrose concentration gradients. 5% dextrose concentrations were plotted to a zero intercept, the slope was steeper than that for more hypertonic dialyses, suggesting loss of efficiency as dialysate dextrose concentration is raised.
200 •• 250 Mean Dextrose Gradient mmol/l FIGURE 3. Ultrafiltration per osmotic gradient decreases as dialysate dextrose (and the dextrose gradient) is increased. 500 r400 UF/osm £ '" ... 'j§ ::;)~ 300 :::0 :::L t +1 200 8 6 100 Dwell Time Concentration 2 36 1275 60 1143 60 4668 t 240 3577 4 .. 0:: :::0 :::L c rt,c 480 3160 2 min mgJdl FIGURE 4. The UP rate and the rate per osmotic gradient are shown in relation to dialysate dextrose concentration and duration of intraperitoneal dwell. High dialysate dextrose and prolonged dwell decrease UF per osmole.
Di Paolo N, Buoncristiani U, Gaggiotti E, et aI. Nephron 1986;44:365-370. Garred U, Canaud B, Farrell PC. ASAIO J 1983;6:131. Breborowicz A, Sombo1os K, Rodela H, Ogilvie R, Bargman J, Oreopoulos D. 1987;7:6-9. Dolkart RE, Lameire N. Peril Dial Bull 1987;7:4-5. Indraprasit S, Sooksriwongse C. Nephron 1985; 40:341-343. Peril Dial Bull II. 42 Physiology, Pharmacology, and Morphology CHAPTER 9 Effect of Cationic Molecules on the Permeability of the Mesothelium in Vitro A. Breborowicz, H. Rodela, J.
Ambulatory Peritoneal Dialysis by M. M. Avram, D. Burrell, P. A. Slater, P. A. Fein, A. Antignani, N. Mittman, D. Tan (auth.), Morrell M. Avram M.D., F.A.C.P., Carmelo Giordano M.D., Natale G. DeSanto M.D., Neal Mittman M.D., Giorgio Bazzato, Paul A. Fein M.D., Amado Gan M.D., Philip Gold