By Ekbia, H. R.
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Additional info for Artificial dreams : the quest for non-biological intelligenc
However, the sensitivity of DAT SPECT and 18F-fluorodopa may be limited, given that some studies have suggested that up to 10% of patients with a clinical diagnosis of PD have normal DAT or fluorodopa activity [57,58]. Whether this is related to clinical misdiagnosis or lack of 17 18 NON-MOTOR SYMPTOMS OF PARKINSON’S DISEASE sensitivity of the diagnostic test remains unresolved. Nonetheless, the patients participating in these trials were considered by their treating neurologist to fulfil diagnostic criteria for PD and this would suggest that in the pre-motor phase with no or few motor symptoms sensitivity could be reduced.
Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders. Arch Neurol 2008; 65: 379–82. 49 Brockmann K, Srulijes K, Hauser AK, et al. GBA-associated PD presents with nonmotor characteristics. Neurology. 2011; 77: 276–80. 50 Gerlach M, Hendrich A, Hueber R, et al. Early detection of Parkinson’s disease: unmet needs. Neurodegener Dis 2008; 5: 137–9. 51 Deems DA, Doty RL, Settle RG, et al. Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center.
There is evidence to support the concept that depression in PD has a biological basis rather than being a pure psychological reaction to having a disabling disease . The occurrence of depression in PD has been suggested to have a bimodal pattern with an initial peak at onset and a second peak in the advanced stages of the disease [25,26]. 27 28 NON-MOTOR SYMPTOMS OF PARKINSON’S DISEASE Santamaria et al.  found that depression was present at the time of evaluation in 32% of patients with PD of recent onset.
Artificial dreams : the quest for non-biological intelligenc by Ekbia, H. R.