By Jonathan A. Cotliar
This atlas presents trainees and practising physicians a visible toolkit to assist realize and deal with this tough situation accurately. this article highlights the scientific variability of GVHD, and hands readers with the diagnostic clues to categorize sufferers in accordance with the present grading/staging instructions. in addition, this atlas deals evidence-based diagnostic and therapy algorithms for physicians to exploit whereas at sufferers' bedsides.
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Additional info for Atlas of Graft-versus-Host Disease: Approaches to Diagnosis and Treatment
Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev. 2010;(8):CD001973. Markiewicz M, Dzierzak-Mietla M, Frankiewicz A, Zielinska P, Koclega A, Kruszelnicka M, et al. Treating oral mucositis with a supersaturated calcium phosphate rinse: comparison with control in patients undergoing allogeneic hematopoietic stem cell transplantation. Support Care Cancer. 2012;20:2223–9. Carpenter PA, Kitko CL, Elad S, Flowers ME, Gea-Banacloche JC, Halter JP, et al.
She K, Gilman AL, Aslanian S, Shimizu H, Krailo M, Chen Z, et al. Altered Toll-like receptor 9 responses in circulating B cells at the onset of extensive chronic graft-versus-host disease. Biol Blood Marrow Transpl. 2007;13(4):386–97. Distinct roles for donor- and host-derived antigen- A. Salhotra and R. Nakamura presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood. 2005;105(5):2227–34. Semin Immunol. 2006;18(5):276–83.
15). tions, psoriasis, eczematous dermatitis, cutaneous T-cell lymphoma, or staphylococcal scalded skin syndrome (SSSS) (Fig. 14). When mucous membrane lesions are present, there are no clinical or histologic differences between skin stage 4 aGVHD and toxic epidermal necrolysis (TEN) [7–9]. If extracutaneous features of aGVHD are present, diagnosis may be possible via tissue confirmation at involved sites. If extracutaneous features of aGVHD are absent, review of clinical symptoms and their development in relation to initiation of medications is mandatory.
Atlas of Graft-versus-Host Disease: Approaches to Diagnosis and Treatment by Jonathan A. Cotliar