By Christos C. Zouboulis
Dermatological learn has skilled a fast improvement within the final twenty years, in spite of the fact that, it has hardly eager about the endocrine capabilities of the surface. just a couple of years in the past clinicians and researchers in dermatology began to discover the surface as a aim organ for many hormones. within the final years the surface has been famous because the biggest endocrine, paracrine and autocrine organ of the physique. it could metabolize steroid hormones and to provide derivatives with almost certainly systemic job. problems of hormone metabolism can both set off direct results at the dermis or ultimately disturb pores and skin homeostasis. Endocrine dermatology is a brand new and intriguing zone of epidermis examine. It comprises epidermis illnesses because of or linked to endocrine problems, epidermis issues which are handled with hormones or with compounds with hormone-like job, and pores and skin issues which take place as opposed occasions of hormone therapy or of therapy with compounds showing a hormone-like influence.
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Additional info for Basic Research in Endocrine Dermatology: 3rd Teupitzer Colloquium, Berlin, September 17-20, 2000 (Special Issue: Hormone Research 2000, 5-6)
Diagnostic Procedures Diagnosis and classification of the SAHA syndrome is based on: (a) the characteristic clinical picture of peripheral hyperandrogenism as well as virilization signs (changes of the voice, increased muscle masses, clitorimegaly and amenorrhoea) and defeminization signs (breast atrophy, decreased rugosity of the vaginal columns, menstrual alterations and sterility), (b) the hereditary predisposition, (c) the typical trichogram examination showing telogen effluvium, particularly in the frontal or frontoparietal area of the scalp, (d) biochemical screening (fig.
Androgen Receptors in Cultured Dermal Papilla Cells from Follicles with Differing Responses to Androgens in vivo Investigations into the mechanism of androgen action in cultured dermal papilla cells from human follicles with various responses to androgens in vivo have revealed the same paradoxes in vitro as seen in vivo. Both androgenstimulated beard  and androgen-inhibited balding scalp  dermal papilla cells contained higher levels of high affinity, low capacity androgen receptors than control non-balding scalp.
23 Elliot K, Stephenson TJ, Messenger AG: Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: Implications for the control of hair follicle size and androgen responses. J Invest Dermatol 1999;113:873–877. 24 Randall VA, Hibberts NA, Thornton MJ, Merrick AE, Hamada K, Kato S, Jenner TJ, De Oliveira I, Messenger AG: Do androgens influence hair growth by altering the paracrine factors secreted by dermal papilla cells? Eur J Dermatol 2001; in press.
Basic Research in Endocrine Dermatology: 3rd Teupitzer Colloquium, Berlin, September 17-20, 2000 (Special Issue: Hormone Research 2000, 5-6) by Christos C. Zouboulis