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Bioinformatics

Bioinformatics and Molecular Evolution - download pdf or read online

By Paul G. Higgs

ISBN-10: 1405106832

ISBN-13: 9781405106832

ISBN-10: 1444311182

ISBN-13: 9781444311181

Within the present period of whole genome sequencing, Bioinformatics and Molecular Evolution presents an up to date and complete advent to bioinformatics within the context of evolutionary biology.

This obtainable textual content:

  • provides an intensive exam of series research, organic databases, trend reputation, and purposes to genomics, microarrays, and proteomics
  • emphasizes the theoretical and statistical tools utilized in bioinformatics courses in a fashion that's available to organic technology students
  • places bioinformatics within the context of evolutionary biology, together with inhabitants genetics, molecular evolution, molecular phylogenetics, and their applications
  • features end-of-chapter difficulties and self-tests to assist scholars synthesize the fabrics and observe their understanding
  • is observed by way of a committed site - www.blackwellpublishing.com/higgs - containing downloadable sequences, hyperlinks to net assets, solutions to self-test questions, and all art in downloadable layout (artwork additionally to be had to teachers on CD-ROM).

This vital textbook will equip readers with an intensive knowing of the quantitative equipment utilized in the research of molecular evolution, and may be crucial examining for complicated undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics classes.

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Additional info for Bioinformatics and Molecular Evolution

Sample text

10 illustrates several points about the data that seem intuitive. There is a cluster of medium-sized hydrophobic residues, I, L, V, M, and F. The two acids, D and E, are close, and so are the two amides, Q and N. Two of the basic residues, R and K, are very close, and H is fairly close to these. The two largest residues, W and Y, are quite close to one another. The PCA diagram manages to do a fairly good job at illustrating all these similarities at the same time. c by F. fr/~fmurtagh/mda-sw/).

DNA polymerase III is able to carry out the addition of new nucleotides to a strand but it cannot initiate a new strand. This is in contrast to RNA polymerase, which is able to perform both initiation and addition. DNA polymerase therefore needs a short sequence, called a primer, from which to begin. Primers are short sequences of RNA (indicated by dotted lines in Fig. 7(d)) that are synthesized by a form of RNA polymerase called primase. 1). Once the fragments on the lagging strand have been synthesized, it is necessary to connect them together.

The UTRs are parts of the sequence that were transcribed but will not be translated. In eukaryotes, the RNA transcript has a more complicated structure (Fig. 7(b)). When the RNA is newly synthesized, it is called a pre-mRNA. It must be processed in several ways before it becomes a functional mRNA. At the 5′ end, a structure known as a cap is added, which consists of a modified G nucleotide and a protein complex called the capbinding complex. , a string of roughly 200 A nucleotides. Proteins called poly-A binding proteins bind to the poly-A tail.

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Bioinformatics and Molecular Evolution by Paul G. Higgs


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