By Teresa K. Attwood, Stephen R. Pettifer, David Thorne
This cutting edge e-book offers a very clean exploration of bioinformatics, investigating its complicated interrelationship with biology and computing device technological know-how. It ways bioinformatics from a special point of view, highlighting interdisciplinary gaps that frequently capture the unwary.
The e-book considers how the necessity for organic databases drove the evolution of bioinformatics; it experiences bioinformatics fundamentals (including database codecs, data-types and present research methods), and examines key subject matters in computing device technology (including data-structures, identifiers and algorithms), reflecting on their use and abuse in bioinformatics.
Bringing those disciplines jointly, this ebook is a vital learn in case you desire to higher comprehend the demanding situations for bioinformatics on the interface of biology and computing device technological know-how, and the way to bridge the gaps. will probably be a useful source for complicated undergraduate and postgraduate scholars, and for teachers, researchers and pros with an curiosity during this attention-grabbing, fast-moving self-discipline and the knotty difficulties that encompass it.
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Extra resources for Bioinformatics challenges at the interface of biology and computer science: mind the gap
How to handle these data, make sense of them, and render them accessible to biologists working on a wide variety of problems is the challenge facing bioinformatics . . The ‘post genomic era’ holds phenomenal promise for identifying the mechanistic bases of organis mal development, metabolic processes, and disease, and we can confidently predict that bioinformatics research will have a dramatic impact on improving our understanding of such diverse areas as the regulation of gene expression, protein structure determination, comparative evolution, and drug discovery (Roos, 2001).
M. et al. 5 Å resolution. Journal of Biological Chemistry, 242, 3984–3988. Zuckerkandl, E. (1987) On the molecular evolutionary clock. Journal of Molecular Evolution, 26, 34–46. Zuckerkandl, E. and Pauling, L. (1965) Molecules as documents of evolutionary history. Journal of Theoretical Biology, 8, 357–366. 7 Quiz The following multiple‐choice quiz will help you to check how much you’ve remem bered of the origins of bioinformatics and computer science described in this chapter. Be mindful that in this and other quizzes throughout the book – just to keep you on your toes – there may be more than one answer!
A great deal of information relating to this diverse array of data is presented in the biomedical literature. In addition, through systematic efforts of researchers and biocurators during the last 40 years, chunks of this information have also been gathered up and stored in databases. We’ll discuss some of these databases in detail later, in Chapter 3. For now, though, to set the scene for those discussions, we’ll begin by introducing some of the fundamental concepts and building‐blocks of molecular biology.
Bioinformatics challenges at the interface of biology and computer science: mind the gap by Teresa K. Attwood, Stephen R. Pettifer, David Thorne