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Download e-book for iPad: Bioinformatics for Comparative Proteomics by Cathy H. Wu, Chuming Chen

By Cathy H. Wu, Chuming Chen

ISBN-10: 1607619768

ISBN-13: 9781607619765

With the fast improvement of proteomic applied sciences within the lifestyles sciences and in medical functions, many bioinformatics methodologies, databases, and software program instruments were constructed to help comparative proteomics learn. In Bioinformatics for Comparative Proteomics, specialists within the box spotlight the present prestige, demanding situations, open difficulties, and destiny traits for constructing bioinformatics instruments and assets for comparative proteomics examine as a way to convey a definitive reference delivering either the breadth and intensity wanted at the topic. dependent in 3 significant sections, this particular quantity covers uncomplicated bioinformatics frameworks in relation to comparative proteomics, bioinformatics databases and instruments for proteomics information research, and built-in bioinformatics platforms and methods for learning comparative proteomics within the structures biology context. Written for the hugely winning tools in Molecular Biology™ sequence, the contributions during this booklet give you the meticulous, step by step description and implementation suggestion that's the most important for purchasing optimum ends up in the lab. accomplished and easy-to-use, Bioinformatics for Comparative Proteomics serves all readers who desire to find out about cutting-edge bioinformatics databases and instruments, novel computational equipment and destiny developments in proteomics information research, and comparative proteomics in structures biology.

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Extra resources for Bioinformatics for Comparative Proteomics

Example text

4. Protein Function Databases The unique feature of proteins that allows their diverse functions is the ability to bind to other molecules specifically. For example, proteins can be enzymes to catalyze the chemical reactions in the cell or to manipulate the replication and transcription of DNA. Many proteins are also involved in the process of cell signaling and signal transduction. Protein function databases maintain information about metabolic pathways, enzymes, compounds, and the inter-molecular interactions and regulatory pathways mechanisms underlying many biological processes.

Geer, L. , Thiessen, P. , Bryant, S. H. (2007) MMDB: annotating protein sequences with Entrez’s 3D-structure database. Nucleic Acids Res. 35, D298–D300. 68. , Webb, B. , Barkan, D. , Marti-Renom, M. , Davis, F. , Sali, A. (2009) MODBASE, a 24 69. 70. 71. 72. 73. Chen, Huang, and Wu database of annotated comparative protein structure models and associated resources. Nucleic Acids Res. 37, D347–D354. , Schwede, T. (2009) The SWISS-MODEL repository and associated resources. Nucleic Acids Res. 37, D387–D392.

Brief. Bioinform. 3, 265–274. , Sigrist, C. J. , Langendijk-Genevaux, P. , Hulo, N. (2006) ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins. Nucleic Acids Res. 34, W362–W365. , Attwood, T. , Finn, R. , Quinn, A. , Selengut, J. , Sigrist, C. , Thomas, P. , Wu, C. , Yeats, C. (2009) InterPro: the integrative protein signature database. Nucleic Acids Res. 37, D211–D215. , Orengo, C. (2008) Gene3D: comprehensive structural and functional annotation of genomes.

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Bioinformatics for Comparative Proteomics by Cathy H. Wu, Chuming Chen


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