By Claus-Wilhelm von der Lieth, Thomas Luetteke, Martin Frank
This e-book is the 1st to be devoted to the bioinformatics of carbohydrates and glycoproteins. It offers an creation to this rising box of technological know-how either for the experimentalist operating in glycobiology and glycomics, and in addition for the pc scientist searching for history info for the advance of hugely refined algorithmic approaches. The e-book offers an outline of the cutting-edge within the box, with experiences on databases, and the instruments in use for research, interpretation, and prediction of the constructions of advanced carbohydrates, and demonstrates the price of bioinformatics for glycobiology.
the supply of entire databases and corresponding bioinformatics instruments, to entry and examine the massive quantities of experimental information on the subject of the constitution of carbohydrates, may be a prerequisite for the luck of the large-scale glycomics initiatives that target to decipher new, to this point unknown, organic services of glycans. Efficient bioinformatics descriptions and instruments can significantly increase the potency of glycomics examine, when it comes to facts caliber, research and experimental charges.
for a whole knowing of the molecular procedures during which carbohydrates are concerned, similar to protein–carbohydrate interactions and the impression of glycosylation on protein functionality, wisdom of the 3D constitution of the carbohydrate, the protein–carbohydrate complicated, or the glycoprotein is frequently quintessential. This ebook offers an intensive advent into equipment used for conformational research of carbohydrates.
Key positive factors:
- Describes bioinformatic techniques to address carbohydrate-active enzymes and glycosylation.
- Provides an summary on bioinformatics instruments that facilitate research of carbohydrate buildings.
- Gives advent into molecular modelling of carbohydrate 3D constitution and carbohydrates inside the Protein Databank.
- Assumes just a uncomplicated wisdom of biology and bioinformatics.
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Extra info for Bioinformatics for Glycobiology and Glycomics: An Introduction
The malarial parasite Plasmodium falciparum expresses GPI in protein anchored and free form on the cell surface: the GPI constitutes a toxin which is implicated in the pathogenesis and fatalities of malaria in humans . Recently, it could be demonstrated that mice vaccinated with a synthetic GPI glycan conjugated to a carrier protein produced anti-GPI antibodies and had a greatly improved chance of survival upon infection with P. falciparum. Between 60 and 75% of vaccinated mice survived, compared with 0–9% of sham-immunized mice.
Subsequent development of associated databases for glycan structures led to the KEGG GLYCAN [16, 66] approach, which elegantly established the connection between glycan structures and the knowledge of enzymatic reactions to 16 Introduction build the glycan structures. Additionally, the KEGG group made significant progress in applying bioinformatics algorithms to the tree-like structures of glycans for comparison and alignment, to develop similarity scores, and to establish a global view of all glycans belonging to related pathways (see also Chapter 7).
On the other hand, synthetic manipulation of glycosylation patterns is being used to advantage in the biotechnological production of recombinant therapeutic glycoproteins; for example, an increase in the number of sialylated glycans on erythropoietin (EPO) increases its serum half-life . An emerging area of research is so-called metabolic oligosaccharide engineering, the goal of which is a biosynthetically altered cell-surface repertoire through the introduction of unnatural sugar residues into cellular glycans.
Bioinformatics for Glycobiology and Glycomics: An Introduction by Claus-Wilhelm von der Lieth, Thomas Luetteke, Martin Frank