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Read e-book online Biological Aspects of Suicidal Behavior PDF

By W.P. Kaschka, D. Rujescu, W.F. Gattaz

ISBN-10: 3318055832

ISBN-13: 9783318055832

Suicide is without doubt one of the most crucial explanations of loss of life in smooth societies. To strengthen more advantageous preventive measures, we need to concentrate on and study extra approximately its neurobiological foundations. in recent times, the instruments of contemporary neurosciences have more and more been applied to symbolize the pathophysiology of complicated human behaviors resembling suicide. to enhance suicide possibility evaluate and suicide prevention, a greater knowing of its pathophysiology is important. This contains study from numerous disciplines akin to neuropsychological, psychosocial and cultural reports but in addition findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. vital effects have, for instance, been got within the box of gene-environment interplay and suicidal habit. we now have simply started to appreciate how early-life adversity may well bring up suicide threat via epigenetic mechanisms. according to such insights, novel healing interventions and preventive measures will be constructed. additionally, a greater knowing of the pathophysiological mechanisms taken with suicidal habit may possibly exhibit the mechanism of compounds like lithium salts. during this publication, suicidal habit and its prevention is mentioned by way of foreign specialists within the mild of the newest effects from a vast spectrum of neurosciences.

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Extra resources for Biological Aspects of Suicidal Behavior

Example text

On the other hand, Gross-Isseroff et al. [46] found decreased α1-adrenergic receptor binding in the PFC, temporal cortex and caudate nucleus of suicide victims. Gonzalez et al. [47] determined α2-adrenergic receptors using the agonist 3H-UK14304 in the hippocampus and frontal cortex and found a significant increase in the number of α2-adrenergic receptors in the CA1 and dentate gyrus and in the external layers of the frontal cortex of suicide subjects. An increase in α2adrenergic receptors was also observed by Meana and Garcia-Sevilla [48] in the frontal cortex of suicide victims.

These results suggest that a pretreatment methylation rate of SLC6A4 is associated with therapeutic responses to antidepressants in unmedicated patients with major depression. Serotonin Receptors in Suicide Serotonin receptors have been classified into several families and subtypes. Of these, 5-HT1A and 5-HT2A receptors have been the most implicated in suicidal behavior. In addition, some reports also show the involvement of 5-HT2C receptors in suicide. 22 Dwivedi Kaschka WP, Rujescu D (eds): Biological Aspects of Suicidal Behavior.

30 Pandey GN, Dwivedi Y, Pandey SC, Teas SS, Conley RR, Roberts RC, Tamminga CA: Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C β1 protein in the prefrontal cortex of teenage suicide subjects. Am J Psychiatry 1999; 156: 1895–1901. 31 Odagaki Y, García-Sevilla JA, Huguelet P, La Harpe R, Koyama T, Guimón J: Cyclic AMP-mediated signaling components are upregulated in the prefrontal cortex of depressed suicide victims. Brain Res 2001; 898: 224–231. 32 Young LT, Bezchlibnyk YB, Chen B, Wang J-F, MacQueen GM: Amygdala cyclic adenosine monophosphate response element binding protein phosphorylation in patients with mood disorders: effects of diagnosis, suicide, and drug treatment.

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Biological Aspects of Suicidal Behavior by W.P. Kaschka, D. Rujescu, W.F. Gattaz


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