By Sandra Braman
This quantity examines the convergence of biotechnology and communique platforms and explores how this convergence without delay impacts our knowing of the character of verbal exchange. Editor Sandra Braman brings jointly students to check this convergence in 3 components: genetic details and ''facticity''; social concerns and implications; and the industrial and criminal matters raised by means of the construction and possession of knowledge. The paintings highlights the delicate procedures happening as biotechnology and knowledge expertise platforms proceed to adapt. The chapters during this ebook method the advanced historical past of this subject and the problems it increases from a couple of instructions. It starts via studying the shared good points and areas of biotechnology and electronic info applied sciences as meta-technologies--qualitatively certain from either the instruments first utilized in the premodern period and the commercial applied sciences that characterised modernity. subsequent, the publication explores what's and isn't beneficial in treating the kinds of data processed by means of the 2 meta-technologies via a shared conceptual lens and appears at matters raised by means of the possession of genetic and electronic info. the ultimate chapters are all in favour of relationships among details and tool. Defining a destiny study time table for conversation scholarship, this paintings is useful to students and scholars in technological know-how conversation, cultural reviews, details applied sciences, and sociology.
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Additional resources for Biotechnology and Communication: The Meta-Technologies of Information (Routledge Communication Series)
A phase III clinical trial with Edifoligide (E2F decoy) was launched by Corgentech, Inc (San Francisco, US). However, the trial was terminated because of its failure to meet the trial’s primary and secondary endpoints, although Edifoligide was generally well tolerated in the 3014-patients that participated in the trial. NF-κB dsDNA Decoy NF-κB is a transcription factor essential for the inflammatory and immunological responses. Through coordinated transactivation, NF-κB upregulates expression of chemokines, interferons, MHC proteins, growth factors, and cell adhesion molecules, whose activation is believed to play a role in diseases such as myocardial infarction and glomerulonephritis.
The parallel or antiparallel polarity of a triplex refers to the direction of the third strand relative to the central Pu strand. (c) Four common triplet DNA structures that contain two types of hydrogen bonds—the normal Watson–Crick type (A = T & G≡C) and Hoogsteen type (A = T & G = CH+)—that involve the N7 of purines (A & G) of the central strand. demonstrated by Felsenfeld et al. using homopurine (Pu) and homopyrimidine (Py) nucleic acids [18, 19]. The most common sequence requirements for triplex formation are double-stranded Pu–Py DNA tracts and a third strand of either Pu or Py oligonucleotide, which is termed TFO.
P1: TIX c02 JWBS053-Johnson November 9, 2010 21:2 Printer Name: Yet to Come ARTIFICIAL MODULATION OF GENE EXPRESSION 27 Locked nucleic acids (LNAs) and the more recent ethylene-bridged nucleic acids (ENAs) have similar structures, in which 2 -O and 4 -C are tethered by either a methylene (strained five-membered ring) or an ethylene bridge (less strained six-membered ring). LNAs or ENAs display very high binding affinity toward RNA ( T m = + 3 to + 8◦ C per modification). Like other 2 -modified oligonucleotides, neither LNAs nor ENAs can activate RNase H.
Biotechnology and Communication: The Meta-Technologies of Information (Routledge Communication Series) by Sandra Braman