By H. C. Hemker (auth.), C. Th. Smit Sibinga, P. C. Das, J. J. van Loghem (eds.)
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Extra info for Bloodtransfusion and Problems of Bleeding
7. : Determinants of factor VIII recovery in cryoprecipitate. Transfusion 15:312, 1975. 8. : The effect of cold on platelets. II. Platelet function after short-term storage at cold temperatures. Blood 40:688, 1972. 9. : Granulocyte concentrate function during preservation: effect of temperature. Blood 54:216, 1979. 10. : Blood Transfusion in Clinical Medicine. 6th Edition. Blackwell, London, 1979, p. 66. 11. : Storage of platelet concentrates at 22 o C. Blood 35:549, 1970. 12. : Neutrophil transfusion: effect of storage and of collection method on neutrophil blood kinetics.
She recovered uneventfully. 20 omitted. Many unexplained abnormalities of platelet behavior are due to drugs such as antihistamines, tranquilizers and S-blockers. The effects of these drugs on platelets vary from individual to individual, and are not widely recognized by the medical and laboratory staff. Finally, if the pattern of abnormality obtained on secondary testing does not fit into a recognizable pattern even after excluding the possibility of technical or clerical error, one of the more unusual combined defects may be present (2).
THE ROLE OF THE PLATELET IN COAGULATION Under physiological circumstances the phospholipids necessary for the coagulation reactions are provided by the blood platelets. It has been shown that the plasma membrane of the platelet is asymmetrical and that the phospholipid composition of the outside has no significant procoagulant properties whereas those at the inside have. Especially phosphatidyl serine (PS) is essential in providing the negative charge that is a prerequisite for binding of the K dependent clotting factors.
Bloodtransfusion and Problems of Bleeding by H. C. Hemker (auth.), C. Th. Smit Sibinga, P. C. Das, J. J. van Loghem (eds.)