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Download e-book for iPad: Botulinum Toxin. Therapeutic Clinical Practice and Science by Joseph Jankovic MD, Alberto Albanese, M. Zouhair Atassi PhD

By Joseph Jankovic MD, Alberto Albanese, M. Zouhair Atassi PhD DSc, J. Oliver Dolly, Mark Hallett, Nathaniel H. Mayer

ISBN-10: 1416049282

ISBN-13: 9781416049289

The recent, therapeutically-focused Botulinum Toxin offers entire, cross-disciplinary information on present practices, overlaying greater than a hundred non-cosmetic stipulations that ensue in neurology, actual drugs and rehabilitation, discomfort medication, ophthalmology, gastroenterology, urology, orthopedics, and surgical procedure. foreign participants evaluate the present figuring out of the biology and mobile mechanisms Read more...

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Additional resources for Botulinum Toxin. Therapeutic Clinical Practice and Science

Example text

27,28 It has been shown that the SYT-II peptide binds at site 2, as suggested previously22 (Fig. 2-5). 19 In addition to providing experimental evidence for the double-receptor model, these structures may also help in identifying small molecules to block either the ganglioside, the protein receptor, or both. Site 1 Site 2 Site 1 Site 2 YEW FIGURE 2-4. Binding domain of tetanus toxin with a tripeptide (Tyr-Glu-Trp) bound at site 2. The tripeptide is shown in sphere model. The orientation is similar to that shown in Figure 2-3.

2000;19:475-487. 83. Arndt JW, Jacobson MJ, Abola EE, Forsyth CM, Tepp WH, Marks JD, et al. A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4. J Mol Biol. 2006;362:733-742. 84. Chenna R, Sugawara H, Koike T, Lopez R, Gibson TJ, Higgins DG, et al. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 2003;31:3497-3500. Catalytic Binding Site 1 Translocation FIGURE 2-1. Ribbons diagram of botulinum neurotoxin type B. The three functional domains are labeled as binding, translocation, and catalytic.

A few interactions are common to all of them, and they all involve conserved residues across serotypes (Fig. 2-8). The sequence numbers corresponding to BoNT/E are used in the FIGURE 2-7. The catalytic domain of BoNT/E shown in ribbons representation. The active site residues, zinc, and the nucleophilic water are shown in ball and stick model. In BoNT/E, the zinc is coordinated by His211, His215, Glu250, and the nucleophilic water. Glu212, which acts as a base for catalytic action, is hydrogen bonded to the nucleophilic water.

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Botulinum Toxin. Therapeutic Clinical Practice and Science by Joseph Jankovic MD, Alberto Albanese, M. Zouhair Atassi PhD DSc, J. Oliver Dolly, Mark Hallett, Nathaniel H. Mayer


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