By Joseph Jankovic MD, Alberto Albanese, M. Zouhair Atassi PhD DSc, J. Oliver Dolly, Mark Hallett, Nathaniel H. Mayer
The recent, therapeutically-focused Botulinum Toxin offers entire, cross-disciplinary information on present practices, overlaying greater than a hundred non-cosmetic stipulations that ensue in neurology, actual drugs and rehabilitation, discomfort medication, ophthalmology, gastroenterology, urology, orthopedics, and surgical procedure. foreign participants evaluate the present figuring out of the biology and mobile mechanisms in addition to appropriate study so that you can simply observe them to the pathophysiology of the varied problems that botulinum toxin is used to regard, resembling botulinum toxin functions for the therapy of cranial-cervical dystonias, motor problems in cerebral palsy, bruxism and temporomandibular problems, headache, overactive bladder, persistent pelvic discomfort syndromes, arthritis joint ache, and wound therapeutic. With discussions of the most recent in authorized remedy practices in addition to new and rising makes use of, you will get in-depth administration information at the software of the toxin. offers scientific functions of botulinum toxin for over a hundred issues for fast entry and simple reference in the course of perform and remedy. Covers a huge array of sizzling subject matters, together with botulinum toxin functions for the remedy of cranial-cervical dystonias, motor problems in cerebral palsy, bruxism and temporomandibular problems, headache, overactive bladder, continual pelvic discomfort syndromes, arthritis joint discomfort, and wound therapeutic. makes a speciality of licensed makes use of with professional recommendation on completely demonstrated purposes but in addition discusses new and rising functions to reveal you to extra treatments. offers the main accomplished and updated fabric to be had so that you get all of the info you wish from this one source. deals the cross-disciplinary information of the simplest world-class services via an authoritative, overseas staff of authors who reveal the purposes of botulinum toxin throughout a variety of specialties. Read more...
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Additional resources for Botulinum Toxin. Therapeutic Clinical Practice and Science
27,28 It has been shown that the SYT-II peptide binds at site 2, as suggested previously22 (Fig. 2-5). 19 In addition to providing experimental evidence for the double-receptor model, these structures may also help in identifying small molecules to block either the ganglioside, the protein receptor, or both. Site 1 Site 2 Site 1 Site 2 YEW FIGURE 2-4. Binding domain of tetanus toxin with a tripeptide (Tyr-Glu-Trp) bound at site 2. The tripeptide is shown in sphere model. The orientation is similar to that shown in Figure 2-3.
2000;19:475-487. 83. Arndt JW, Jacobson MJ, Abola EE, Forsyth CM, Tepp WH, Marks JD, et al. A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4. J Mol Biol. 2006;362:733-742. 84. Chenna R, Sugawara H, Koike T, Lopez R, Gibson TJ, Higgins DG, et al. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 2003;31:3497-3500. Catalytic Binding Site 1 Translocation FIGURE 2-1. Ribbons diagram of botulinum neurotoxin type B. The three functional domains are labeled as binding, translocation, and catalytic.
A few interactions are common to all of them, and they all involve conserved residues across serotypes (Fig. 2-8). The sequence numbers corresponding to BoNT/E are used in the FIGURE 2-7. The catalytic domain of BoNT/E shown in ribbons representation. The active site residues, zinc, and the nucleophilic water are shown in ball and stick model. In BoNT/E, the zinc is coordinated by His211, His215, Glu250, and the nucleophilic water. Glu212, which acts as a base for catalytic action, is hydrogen bonded to the nucleophilic water.
Botulinum Toxin. Therapeutic Clinical Practice and Science by Joseph Jankovic MD, Alberto Albanese, M. Zouhair Atassi PhD DSc, J. Oliver Dolly, Mark Hallett, Nathaniel H. Mayer