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Download e-book for kindle: Brain Repair After Stroke by Steven C. Cramer MD, Randolph J. Nudo PhD

By Steven C. Cramer MD, Randolph J. Nudo PhD

ISBN-10: 0521515335

ISBN-13: 9780521515337

Expanding facts identifies the potential for restoring functionality to the broken mind through exogenous treatments. One significant objective for those advances is stroke, the place so much sufferers may be left with major incapacity. remedies have the aptitude to enhance the victim's caliber of existence considerably and decrease the time and price of rehabilitation. mind fix After Stroke stories the biology of spontaneous mind fix after stroke in animal versions and in people. particular chapters hide the numerous sorts of treatment being explored to advertise mind fix and view medical trial matters during this context. This ebook offers a precis of the neurobiology of innate and treatment-induced fix mechanisms after hypoxia and studies the state-of-the-art for human therapeutics on the subject of selling behavioral restoration after stroke. crucial interpreting for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.

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2001;914:1–14. 36. Kartje GL, Schulz MK, Lopez-Yunez A, et al. Corticostriatal plasticity is restricted by myelinassociated neurite growth inhibitors in the adult rat. Ann Neurol. 1999;45:778–86. 46. Miller FD, Geddes JW. Increased expression of the major embryonic alpha-tubulin mRNA, T alpha 1, during neuronal regeneration, sprouting, and in Alzheimer’s disease. Prog Brain Res. 1990;86:321–30. 47. Tanaka H, Yamashita T, Asada M, et al. Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity.

One adjunct to motor rehabilitative training that we have investigated is low-intensity cortical electrical stimulation (CS). In rats and monkeys with motor cortical infarcts, epi- or subdural CS delivered for 10–30 days over remaining regions of the motor cortex during daily practice in skilled reaching improves functional outcome compared with reach training alone [63]. A related approach under investigation in human stroke survivors is the use of noninvasive transcranial stimulation to modulate cortical activity [64].

Transcriptional regulation of neurogenesis: Potential mechanisms in cerebral ischemia. J Mol Med. 2007;85:577–88. 31. Arlotta P, Molyneaux BJ, Chen J, et al. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron. 2005;45:207–21. 32. Deguchi K, Takaishi M, Hayashi T, et al. Expression of neurocan after transient middle cerebral artery occlusion in adult rat brain. Brain Res. 2005;1037:194–9. 33. Eslamboli A, Grundy RI, Irving EA. Time-dependent increase in Nogo-A expression after focal cerebral ischemia in marmoset monkeys.

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Brain Repair After Stroke by Steven C. Cramer MD, Randolph J. Nudo PhD


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