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Download PDF by Duward F. Shriver, M. A. Drezdzon: Manipulation of air sensitive compounds

By Duward F. Shriver, M. A. Drezdzon

ISBN-10: 047186773X

ISBN-13: 9780471867739

Revised to mirror the ongoing and turning out to be significance of analysis and improvement inside this box, The Manipulation of Air-Sensitive Compounds, 2d variation bargains state of the art tools utilized in dealing with air-sensitive compounds, together with gases. half One covers inert surroundings strategies, whereas half treats vacuum line thoughts. Appendixes supply safeguard info, details on fabrics used to build gear, and a desk of vapor pressures of universal unstable elements.

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Exposure route/Concentrations/Durations: Aerosol inhalation; LCt50 of 37,000 mg-min/m3 based on exposure durations of 6-25 min. Effects: LCt50 of 37,000 mg-min/m3 based on exposure durations of 6-25 min. End point/Concentration/Rationale: Lethality threshold estimated as one-tenth of LCt50; definitive information regarding the concentration-response relationship for BZ is lacking. Uncertainty factors/Rationale: Total uncertainty factor: 100 Interspecies: 10, no lethality data are available for humans and LCt50 values for five animal species varied 10-fold.

10(6):861-867. 34 Acute Exposure Guideline Levels APPENDIX A DERIVATION OF AEGL VALUES FOR AGENT BZ Derivation of AEGL-1 Values Although exposures to BZ resulting in no apparent effects in animals were available, the experiments could not assess possible cognitive and behavioral effects characteristic of BZ that are relevant to humans. Human data on BZ that define no-effect levels or that are consistent with the AEGL-1 definition were not available. Thus, AEGL-1 values for BZ are not recommended.

R. Franz, eds. Office of the Surgeon General at TMM Publications, Borden Institute, Walter Reed Army Medical Center, Washington, DC. R. B. L. E. Vancil. 1967. The Human Assessment of BZ Disseminated Under Field Conditions. Edgewood Arsenal Technical Report EATR 4140. Medical Research Laboratory, Edgewood Arsenal, MD. , W. A. DeYoung. 2001. Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene. Pharm. Sci. 3(4):57-61. P. 1963. Toxicological Studies of Effects of BZ on Animals.

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Manipulation of air sensitive compounds by Duward F. Shriver, M. A. Drezdzon

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