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Multidisciplinary Treatment of Soft Tissue Sarcomas by J. M. Coindre (auth.), Jaap Verweij, Herbert M. Pinedo, PDF

By J. M. Coindre (auth.), Jaap Verweij, Herbert M. Pinedo, Herman D. Suit (eds.)

ISBN-10: 1461363462

ISBN-13: 9781461363460

ISBN-10: 1461530822

ISBN-13: 9781461530824

The prior quantity of this sequence on smooth tissue sarcomas highlighted the significance of the multidisciplinary method of therapy, the point of interest of that is persevered within the current variation. right prognosis and staging stay the cornerstone of the therapy approach. subtle histopathology innovations and starting to be consensus on grading platforms have extra elevated the significance of the histopathologist in delivering estimates of the analysis of the sufferer in addition to offering info for the making plans of remedy procedure. using cytogenetics is comparatively new during this box. this is able to allow the excellence of subgroups in particular histological tumor varieties. additionally, molecular organic reviews not just aid to bare inherited predispositions and information in oncogenesis in tumor improvement, yet they might additionally supply extra predictive elements for tumor habit. extra facts on therapy process should be supplied via diagnostic imaging, a box during which the function of magnetic resonance imaging is quickly constructing. so far as genuine remedy is worried, surgical procedure nonetheless presents the most important probability for therapy. In view of the undertaking to be as sparing as attainable, the addition of radiotherapy to surgical procedure is of extreme significance. often radiotherapy is given after surgical procedure, however the optimum series of the 2 modalities nonetheless should be outlined. The mixed use of surgical procedure with radiotherapy and/or chemotherapy does influence wound healing.

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Involvement of chromosome X in primary cytogenetic change in human neoplasia: Nonrandom translocation in synovial sarcoma. Proc Natl Acad Sci USA 84:1981-1985, 1987. 25. : Cytogenetics of synovial sarcoma: Presentation of ten new cases and review of the literature. Gene Chromosome Cancer 3:338-345,1991. 26. : Cytogenetic findings in two synovial sarcomas. Cancer Genet Cytogenet 38:215-222,1989. 27. Verhest A, Limon J, Mrozek K, Nedoszytko B: Translocations t(X;7) and t(7;14) in a synovial sarcoma.

Cancer 62:994-998, 1988. 49. Lack EE, Steinberg SM, White DE, Kinsella T, Glatstein E, Chang AE, Rosenberg SA: Extremity soft tissue sarcomas: Analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher-grade sarcomas. J Surg Oncol 41: 263-273, 1989. 50. Elias A, Ryan L, Sulkes A, Collins J, Aisner J, Antman KH: Response to mesna, doxorubicin, ifosfamide and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.

Recently Malkin et a1. [22] and Srivastava et a1. [23] have detected germline mutations in the p53 suppressor gene (located at chromosome 17p13) in Li-Fraumeni families, suggesting that inherited mutations in this gene are responsible for the development of diverse selection of tumors associated with this syndrome. 8 Figure 1. Li-Fraumeni pedigree. Symbols represent females with cancer (e), females without cancer, (0), males with cancer (_), males without cancer (0), and the presence of a constitu· tional mutation the p53 gene (*).

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Multidisciplinary Treatment of Soft Tissue Sarcomas by J. M. Coindre (auth.), Jaap Verweij, Herbert M. Pinedo, Herman D. Suit (eds.)


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