By American Academy of Neurology
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Extra resources for Neurology Volume 72(2) January 13, 2009
Because WHIMS-MRI was primarily designed to provide mechanistic support for the findings of the WHIMS trials, no adjustment for comparisons of its multiple endpoints was specified in its protocol. Associations between MRI outcomes and dementia risk factors were assessed with analyses of covariance. To test the hypothesis that the effect of HT on MRI volumes varied by baseline 3MS, we fitted an interaction term between treatment effect and baseline 3MS scores as a continuous variable and presented fitted means for women grouped by baseline scores.
All observers were blinded to patient data. After manual identification of lacunar infarcts, they were also marked on the MRI segmentations. Statistics. K. L. van der Neut, and J. van der Grond, all from the Department of Radiology of the Leiden University Medical Center. , Chicago, IL). Differences between MCs and nonMCs in demographic variables, MRI parameters, and neuropsychological testing results at baseline were analyzed using Student t tests for the normally distributed continuous variable Wechsler Memory Scale memory quotient, Mann–Whitney U test for the other non-normally distributed continuous variables, and 2 tests for categorical variables.
Neuroimage 2004;21:364–371. Shaywitz SE, Shaywitz BA, Pugh KR, et al. Effect of estrogen on brain activation patterns in postmenopausal women during working memory tasks. JAMA 1999;281: 1197–1202. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321–333. , for the Women’s Health Initiative Memory Study. Postmenopausal hormone therapy and subclinical cerebrovascular disease: the WHIMS-MRI Study.
Neurology Volume 72(2) January 13, 2009 by American Academy of Neurology