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Download e-book for iPad: Neuroprotection in Brain Ischemia: An Update by M. Kaste, J. Castillo

By M. Kaste, J. Castillo

ISBN-10: 380558122X

ISBN-13: 9783805581226

Complement factor: Cerebrovascular ailments 2006, Vol. 21, Suppl. 2

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Extra resources for Neuroprotection in Brain Ischemia: An Update (Cerebrovascular Diseases 2006)

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1 to normalize electric brain activity and reduce infarct size [20]. Also an inducer of HSP-70 expression, geranylgeranylacetone showed in an animal model of MCAO that it significantly reduces infarct volume when administered very early [21]. Finally, ␤-lactam antibiotics seem to offer neuroprotection by increasing glutamate transporter GLT1 (or EAAT2) expression. In short, ceftriaxone has been demonstrated to be a potent stimulator of GLT1 expression in brain of animals, as well as its biochemical and functional activity [22].

Pharmacotherapy 2005;25:387–395. 42 Scandinavian Simvastatin Survival Study Group: Randomised trial of cholesterol lowering in 4,444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383–1389. 43 Blauw GJ, Lagaay AM, Smelt AHM, Westendorp RGJ: Stroke, statins, and cholesterol: a meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors. Stroke 1997;28:946–950. 44 Crouse JR III, Byington RP, Hoen HM, Furberg CD: Reductase inhibitor monotherapy and stroke prevention.

However, O2– is the one that generates oxidative stress in ischemic brain [7, 16]. Recently, the presence of ROS produced by an increased expression of NOX4 (NADPH oxidase isoform) has been demonstrated in cortical neurons. NOX4 could exert a role in the angiogenesis induced by ischemia/hypoxia since it is overexpressed in newly formed capillaries [17]. Ischemic brain also originates from a high production of NO which it is synthesized from L-arginine through NOS [18]. The effect of NO increase can be neurotoxic or neuroprotective according to the NOS isoform starting from which is synthesized.

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Neuroprotection in Brain Ischemia: An Update (Cerebrovascular Diseases 2006) by M. Kaste, J. Castillo


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