By Etienne-Emile Baulieu
Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of wonderful scientists and medical researchers exhaustively and significantly overview all elements of neurosteroids thinking about habit, rigidity, reminiscence, melancholy, anxiousness, getting older of the mind, and neurodegenerative illnesses. those participants light up the position of neurosteroids in mind improvement and plasticity and element their neuromodulatory impact on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. sincerely pointing the best way towards novel pharmaceutical brokers which may be of vital healing price, rather with reference to getting older psychological features, Neurosteroids: a brand new Regulatory functionality within the fearful procedure bargains neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the 1st entire, cutting-edge assessment of those vital bioactive molecules.
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Additional info for Neurosteriods: A New Regulatory Function in the Nervous System (Contemporary Endocrinology)
Using RNase protection assays, we did not detect P450scc mRNA in any of the tissues analyzed. However P450c11` mRNA (11` hydroxylase), but not the mRNAs for P450c11AS (aldosterone synthase) or P450c17 (17_ hydroxylase), was detected by RNase protection assays. We could only detect P450scc mRNA, but not P450c17 nor P450c11AS mRNA, in our primary glial cultures or rat brains after amplification of RNA by polymerase chain reaction (PCR) and Southern blotting, thus indicating that the abundance of this mRNA was extremely low.
Guth L, Zhang Z, Roberts E. Key role for pregnenolone in combination therapy promotes recovery after spinal cord injury. Proc Natl Acad Sci USA 1994;91:12,308–12,312. 118. Yu WH. Survival of motoneurons following axotomy is enhanced by lactation or by progesterone treatment. Brain Res 1989;491:379–382. 119. Roof RL, Duvdevani R, Stein DG. Gender influences outcome of brain injury—Progesterone plays a protective role. Brain Res 1993;607:333–336. 120. Warembourg M, Otten U, Schwab ME. Labelling of Schwann and satellite cells by [ 3H] dexamethasone in a rat sympathetic ganglion and sciatic nerve.
The names of the enzymes are shown for each reaction. P450scc, cholesterol side-chain cleavage; 3`HSD, 3` hydroxysteroid dehydrogenase/isomerase; P450c17, 17_ hydroxylase/c17,20 lyase; P450c21, 21 hydroxylase; P450c11`, 11` hydroxylase; P450c11AS, aldosterone synthase; P450c11B3, developmentallyregulated 11` hydroxylase/18 hydroxylase; 17`HSD, 17` hydroxysteroid dehydrogenase/17 ketosteroid reductase; P450aro, aromatase. “ZF/R” refers to the adrenal zona fasciculata/reticularis and “ZG” refers to the adrenal zona glomerulosa.
Neurosteriods: A New Regulatory Function in the Nervous System (Contemporary Endocrinology) by Etienne-Emile Baulieu