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By Sanjay Ghosh

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Stimulation of human toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation. Cell Microbiol. 2004;6(2):187–99. 38. Palsson-McDermott EM, Doyle SL, McGettrick AF, et al. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88- independent TLR4 pathway. Nat Immunol. 2009;10:579–86. 39. Shi M, Deng W, Bi E, et al. TRIM30a negatively regulates TLR-mediated NF-jB activation by targeting TAB2 and TAB3 for degradation Nat Immunol.

12. Kollisch G, Kalali BN, Voelcker V, et al. Various members of the toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology. 2005;114(4):531–41. 13. Miller LS, Sorensen OE, Liu PT, et al. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005;174(10):6137–43. 14. Lebre MC, van der Aar AM, van Baarsen L, et al. Human keratinocytes express functional toll-like receptor 3, 4, 5, and 9. J Invest Dermatol. 2007;127:331–41.

Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic psoriasis. Br J Dermatol. 2003;148:670–9. 80. Begon E, Michel L, Flageul B, et al. Expression, subcellular localization and cytokine modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin. Eur J Dermatol. 2007;17:497–506. 81. Lande R, Gregorio J, Facchinetti V, et al. Plasmacytoid dendritic cells sense selfDNA coupled with antimicrobial peptide.

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Recent Advances in Dermatology by Sanjay Ghosh

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