By T. M. Kündig (auth.), Prof. Dr. Günter Burg M.D., PD Dr. Reinhard G. Dummer M.D. (eds.)
Recent growth within the fields of pharmacology and immunology has supplied us with new probabilities for treating dermatological ailments. This booklet experiences an important immunosuppressive and immunostimulatory medications and provides priceless, sensible info at the remedy of varied dermatoses, together with autoimmundiseases, atopic dermatitis, psoriasis, vasculitis, touch dermatitis, pyoderma gangrenosum, infectious ailments, and neoplasms of the surface - specifically, malignant melanoma.
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Contemporary growth within the fields of pharmacology and immunology has supplied us with new probabilities for treating dermatological ailments. This ebook studies an important immunosuppressive and immunostimulatory medicines and offers necessary, functional details at the remedy of varied dermatoses, together with autoimmundiseases, atopic dermatitis, psoriasis, vasculitis, touch dermatitis, pyoderma gangrenosum, infectious illnesses, and neoplasms of the surface - particularly, malignant cancer.
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Extra resources for Strategies for Immunointerventions in Dermatology
Wollenberg A, Kraft S, Hanau D, Bieber T (1996) Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema. J Invest DermatolI06:446-453 11. Matzinger P (1994) Tolerance, danger, and the extended family. Annu Rev Immunol 12:991-1045 12. Van Reijsen FC,Bruijnzeel-Koomen CAFM, Kalthoff FS, Maggi E,Romagnani S, Westland JKT, Mudde GC (1992) Skin derived aeroallergen-specific T cell clones of Th2 phenotype in patients with atopic dermatitis.
It is clear from the literature that CsA is immunosuppressive and anti -inflammatory, and it is not surprising that CsA has been successful to date in treating certain skin diseases, including psoriasis, atopic dermatitis, and others with inflammatory and immunological components. , the KC. KC can become hyperproliferative and secrete chemotactic and immunostimulatory cytokines that are increased and even dysregulated in certain skin diseases such as psoriasis. Since CsA has been shown to inhibit proliferation and cytokine secretion in immunocytes, the question remains whether its clinical success in dermatology is due in part to its ability to directly inhibit these activities in KC.
36 T. Wrone-Smith and B. J. Nickoloff Experimental data support the efficacy of CsA treatment in psoriasis is due to diminution of T cell activation in plaques with decreased subsequent lymphokine production. , IL-2R+ HLA-DR+, T cells is noted in lesions following CsA treatment. In addition, expression of the activation markers HLA-DR and intercellular adhesion molecule (ICAM)-I on KC and endothelial cells, and the secretion of the chemokine IP-IO by KC, all induced by in vivo exposure to lymphokines such as IFN -y, are decreased following CsA treatment .
Strategies for Immunointerventions in Dermatology by T. M. Kündig (auth.), Prof. Dr. Günter Burg M.D., PD Dr. Reinhard G. Dummer M.D. (eds.)