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Systems Biology: Simulation of Dynamic Network States by Bernhard Ø. Palsson PDF

By Bernhard Ø. Palsson

ISBN-10: 1107001595

ISBN-13: 9781107001596

Biophysical types were utilized in biology for many years, yet they've been restricted in scope and dimension. during this booklet, Bernhard Ø. Palsson indicates how community reconstructions which are in response to genomic and bibliomic info, and take the shape of validated stoichiometric matrices, might be switched over into dynamic types utilizing metabolomic and fluxomic facts. The Mass motion Stoichiometric Simulation (MASS) approach can be utilized for any mobile procedure for which facts is obtainable and permits a scalable step by step method of the sensible development of community types. particularly, it may well deal with built-in methods that desire particular accounting of small molecules and protein, which permits simulation on the molecular point. the fabric has been class-tested through the writer at either the undergraduate and graduate point. All computations within the textual content can be found on-line in MATLAB and MATHEMATICA® workbooks, permitting hands-on perform with the cloth.

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Download e-book for kindle: Systems Biology: Simulation of Dynamic Network States by Bernhard Ø. Palsson

Biophysical types were utilized in biology for many years, yet they've been constrained in scope and measurement. during this ebook, Bernhard Ø. Palsson exhibits how community reconstructions which are in keeping with genomic and bibliomic information, and take the shape of proven stoichiometric matrices, might be switched over into dynamic versions utilizing metabolomic and fluxomic info.

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Extra resources for Systems Biology: Simulation of Dynamic Network States

Sample text

This number multiplied by 2 would be the total number of highenergy phosphate bonds that can be stored in this system. The second variable that we can define here would be the occupancy of that capacity, 2ATP + ADP, which is simply an enumeration of how much of that capacity is occupied by high-energy phosphate bonds. Notice that the occupancy variable has a conjugate pair, which would be the vacancy variable. C. 18) which is a variable that varies between 0 and 1. This quantity is the energy charge defined by Daniel Atkinson [13].

Xm ... x1 ... t ... 1 The fundamental structure of the file x(t) that results from a numerical simulation. The two vertical bars show the list of values that would be used to compute σ12 (2) (see Eq. 8)); that is, the correlation between x1 and x2 with a time lag of 2. can be expanded as dx = Sv(x) = dt si vi (x). 2) In other words, the time derivatives are linear combinations of the reaction vectors (si ) weighted by the reaction rates, which in turn change with the concentrations that are time varying.

Courtesy of Neema Jamshidi [53]. 5 Network structure versus dynamics 31 Multiple time scales In reality there are many more than three time scales in a realistic network. 9. The formation of such hierarchies will be discussed in Parts III and IV of the text. 5 Network structure versus dynamics The stoichiometric matrix represents the topological structure of the network, and this structure has significant implications with respect to what dynamic states a network can take. Its null spaces give us information about pathways and pools.

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Systems Biology: Simulation of Dynamic Network States by Bernhard Ø. Palsson

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