By Peter Ramwell
There is way facts to indicate that prostaglandins can have a physiological function to play within the keep watch over of thyroid gland metabolism, even supposing the perfect nature of this function is still outlined. Prostaglandins were present in general thyroid tissue, and there's proof of elevated degrees in a few, yet now not all, circumstances of medullary carcinoma of the thyroid. that may account for the linked diarrhea. Exogenous prostaglandins, like TSH, bind to thyroid plasma mem branes, stimulate the adenylate cyclase-cyclic AMP process, thyroid hormone secretion, iodide organification, colloid droplet formation, glucose oxidation, and 32p incorporation into phospholipids. Prosta glandins of the E sequence are the main powerful, even if their maximal results are regularly below the maximal results of TSH. The interrelationships latest among TSH and prostaglandins were the topic of extensive research, yet as but nobody uni fying proposal has emerged. TSH and prostaglandins were proven to occupy various receptors at the thyroid plasma membrane. Al although TSH can elevate intracellular prostaglandin degrees, most likely due to elevated synthesis, prostaglandins don't seem to be crucial intermediates in TSH motion on adenylate cyclase. The pos sibility that prostaglandins are a part of a unfavorable suggestions method con trolling TSH motion is, as but, a tentative speculation, and extra paintings should be required to resolve the interrelationships among those sub stances that now seem to be way more advanced than has been envisaged hence far.
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Additional resources for The Prostaglandins: Volume 2
From these and other results, they concluded that prostaglandin E2 mediates the functional dilatation and furthermore that it originates from the triglycerides of the fat rather than from the phospholipids of the cell membranes. 3. , 1971). , 1971). As could be predicted, in endotoxin shock there are increased levels of prostaglandins in venous blood: this has been shown by Collier et al. (1973), who measured prostaglandin-like activity in renal venous blood, and by Kessler et al. (1973), who found both prostaglandin E and prostaglandin A-like material in "plasma" from an unspecified vessel of dogs.
Orczyk, G. , and Greep, R. , 1972, Effect of synthetic gonadotrophin-releasing hormone (Gn-RH) on ovulation blockade by aspirin and indomethacin, Prostaglandins 1: 245. , 1971, Studies on prostaglandin antagonists, Brit. J. Pharmacol 42: 584. , Friedman, C. , and Vane, J. ) 216: 873. , Stamford, I. , and Unger, W. , 1973, Prostaglandin E2 and gastric acid secretion in man, J. Physiol. ) 229: 349. , von Euler, U. , 1959, Observations on the effects of infusions of prostaglandin E in man, Acta Physiol.
The results which follow also show clearly that local prostaglandin release in some organs has a physiological function to modulate vessel tone. F. Local Regulation of Blood Flow 1. , 1970a, b, 1972a, b). 34 Aspirin and Prostaglandins Coincident with this release, there is partial recovery of the renal blood flow. These results suggest that endogenous prostaglandin E2 , which is a renal vasodilator (Weeks, 1972), acts as a physiological antagonist to renal vasoconstrictor substances. Aiken and Vane (1971, 1973) confirmed these results and further showed that indomethacin or mec1ofenamate reduced renal blood flow and urine output but not blood pressure or hind limb blood flow.
The Prostaglandins: Volume 2 by Peter Ramwell